Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor—α: Potential Cause for Mucoid Otitis Media
Identifieur interne : 003656 ( Main/Exploration ); précédent : 003655; suivant : 003657Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor—α: Potential Cause for Mucoid Otitis Media
Auteurs : Jizhen Lin [États-Unis] ; Atsushi Haruta [États-Unis] ; Hirokazu Kawano [États-Unis] ; Samuel B. Ho [États-Unis] ; George L. Adams [États-Unis] ; Steven K. Juhn [États-Unis] ; Youngki Kim [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2000.
Abstract
Mucoid otitis media (MOM) is characterized by viscous fluid, high in mucin concentration, which accumulates in the middle ear cavity. Recent studies suggest that initial infection in the middle ear cleft may be key to the development of MOM. However, factors of the initial infection attributed to the stimulation of mucin production are not clearly understood. This study demonstrated that tumor necrosis factor (TNF)—α, a proinflammatory cytokine in mucoid effusion, markedly increased Muc2 mucin mRNA expression in middle ear epithelium, in a time- and dose-dependent manner. Parallel to this was a marked increase in mucin glycoprotein in middle ear fluid. Also, TNF-α demonstrated an autocrine and/or paracrine effect on the expression of endogenous TNF-α gene in the middle ear, which may contribute to the production of mucin in this study. These findings suggest that TNF-α plays an important role in the development of MOM by stimulating mucin metabolism.
Url:
DOI: 10.1086/315767
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001552
- to stream Istex, to step Curation: 001552
- to stream Istex, to step Checkpoint: 000F55
- to stream Main, to step Merge: 003698
- to stream Main, to step Curation: 003656
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor—α: Potential Cause for Mucoid Otitis Media</title><author><name sortKey="Lin, Jizhen" sort="Lin, Jizhen" uniqKey="Lin J" first="Jizhen" last="Lin">Jizhen Lin</name></author><author><name sortKey="Haruta, Atsushi" sort="Haruta, Atsushi" uniqKey="Haruta A" first="Atsushi" last="Haruta">Atsushi Haruta</name></author><author><name sortKey="Kawano, Hirokazu" sort="Kawano, Hirokazu" uniqKey="Kawano H" first="Hirokazu" last="Kawano">Hirokazu Kawano</name></author><author><name sortKey="Ho, Samuel B" sort="Ho, Samuel B" uniqKey="Ho S" first="Samuel B." last="Ho">Samuel B. Ho</name></author><author><name sortKey="Adams, George L" sort="Adams, George L" uniqKey="Adams G" first="George L." last="Adams">George L. Adams</name></author><author><name sortKey="Juhn, Steven K" sort="Juhn, Steven K" uniqKey="Juhn S" first="Steven K." last="Juhn">Steven K. Juhn</name></author><author><name sortKey="Kim, Youngki" sort="Kim, Youngki" uniqKey="Kim Y" first="Youngki" last="Kim">Youngki Kim</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8834A29A576FC54DF337614048EF5CA0F08063F5</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1086/315767</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-XV76BB0D-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001552</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001552</idno><idno type="wicri:Area/Istex/Curation">001552</idno><idno type="wicri:Area/Istex/Checkpoint">000F55</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000F55</idno><idno type="wicri:doubleKey">0022-1899:2000:Lin J:induction:of:mucin</idno><idno type="wicri:Area/Main/Merge">003698</idno><idno type="wicri:Area/Main/Curation">003656</idno><idno type="wicri:Area/Main/Exploration">003656</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor—<hi rend="italic">α</hi>: Potential Cause for Mucoid Otitis Media</title><author><name sortKey="Lin, Jizhen" sort="Lin, Jizhen" uniqKey="Lin J" first="Jizhen" last="Lin">Jizhen Lin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Otolaryngology, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Jizhen Lin, Room 216, Lions Research Bldg., 2001 6th St. SE</wicri:cityArea></affiliation></author><author><name sortKey="Haruta, Atsushi" sort="Haruta, Atsushi" uniqKey="Haruta A" first="Atsushi" last="Haruta">Atsushi Haruta</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Otolaryngology, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Kawano, Hirokazu" sort="Kawano, Hirokazu" uniqKey="Kawano H" first="Hirokazu" last="Kawano">Hirokazu Kawano</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Otolaryngology, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Ho, Samuel B" sort="Ho, Samuel B" uniqKey="Ho S" first="Samuel B." last="Ho">Samuel B. Ho</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Medicine, Minneapolis</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Veterans Affairs Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Adams, George L" sort="Adams, George L" uniqKey="Adams G" first="George L." last="Adams">George L. Adams</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Otolaryngology, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Juhn, Steven K" sort="Juhn, Steven K" uniqKey="Juhn S" first="Steven K." last="Juhn">Steven K. Juhn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Otolaryngology, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Youngki" sort="Kim, Youngki" uniqKey="Kim Y" first="Youngki" last="Kim">Youngki Kim</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Otitis Media Research Center, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2000</date><biblScope unit="vol">182</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="882">882</biblScope><biblScope unit="page" to="887">887</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Mucoid otitis media (MOM) is characterized by viscous fluid, high in mucin concentration, which accumulates in the middle ear cavity. Recent studies suggest that initial infection in the middle ear cleft may be key to the development of MOM. However, factors of the initial infection attributed to the stimulation of mucin production are not clearly understood. This study demonstrated that tumor necrosis factor (TNF)—α, a proinflammatory cytokine in mucoid effusion, markedly increased Muc2 mucin mRNA expression in middle ear epithelium, in a time- and dose-dependent manner. Parallel to this was a marked increase in mucin glycoprotein in middle ear fluid. Also, TNF-α demonstrated an autocrine and/or paracrine effect on the expression of endogenous TNF-α gene in the middle ear, which may contribute to the production of mucin in this study. These findings suggest that TNF-α plays an important role in the development of MOM by stimulating mucin metabolism.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Lin, Jizhen" sort="Lin, Jizhen" uniqKey="Lin J" first="Jizhen" last="Lin">Jizhen Lin</name></region><name sortKey="Adams, George L" sort="Adams, George L" uniqKey="Adams G" first="George L." last="Adams">George L. Adams</name><name sortKey="Haruta, Atsushi" sort="Haruta, Atsushi" uniqKey="Haruta A" first="Atsushi" last="Haruta">Atsushi Haruta</name><name sortKey="Ho, Samuel B" sort="Ho, Samuel B" uniqKey="Ho S" first="Samuel B." last="Ho">Samuel B. Ho</name><name sortKey="Ho, Samuel B" sort="Ho, Samuel B" uniqKey="Ho S" first="Samuel B." last="Ho">Samuel B. Ho</name><name sortKey="Juhn, Steven K" sort="Juhn, Steven K" uniqKey="Juhn S" first="Steven K." last="Juhn">Steven K. Juhn</name><name sortKey="Kawano, Hirokazu" sort="Kawano, Hirokazu" uniqKey="Kawano H" first="Hirokazu" last="Kawano">Hirokazu Kawano</name><name sortKey="Kim, Youngki" sort="Kim, Youngki" uniqKey="Kim Y" first="Youngki" last="Kim">Youngki Kim</name><name sortKey="Lin, Jizhen" sort="Lin, Jizhen" uniqKey="Lin J" first="Jizhen" last="Lin">Jizhen Lin</name><name sortKey="Lin, Jizhen" sort="Lin, Jizhen" uniqKey="Lin J" first="Jizhen" last="Lin">Jizhen Lin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003656 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003656 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8834A29A576FC54DF337614048EF5CA0F08063F5
|texte= Induction of Mucin Gene Expression in Middle Ear of Rats by Tumor Necrosis Factor—α: Potential Cause for Mucoid Otitis Media
}}
| This area was generated with Dilib version V0.6.33. |  |